The set-up: San Francisco has an above-average pass defense, which Aaron Rodgers and the Packers have struggled against, but after losing both teams to the 49rs last year, I expect Green Bay to bounce back off a loss last weekend, to avenge those two setbacks from last season, and to take advantage of this once again severely depleted 49ers side. San Francisco had won two in a row, but it came up short in last week's 37-27 loss in Seattle. The 49ers though lost the services of their two best players in the setback as well, as QB Jimmy Garoppolo and dynamic playmaking TE George Kittle are both now out with injury for several weeks.

The pick: Very much a common sense play here. Green Bay has all the motivation it needs to win this game, while all signs point to massive regression from this San Francisco team that continues to deal with adversity. Consider laying the points.

This is a 1* FREE PLAY on the PACKERS.