The set-up: This is an important non-conference game for both teams. The Bills are 8-3 and the 49ers are 5-6. Buffalo beat the Chargers 27-17 last time out, while the 49ers beat the Rams 23-20 on the road. Buffalo is going to try and push the tempo of this one, as it comes to the West Coast averaging 27.2 PPG, while allowing 25.6. Josh Allen has emerged this season as one of the top QB's, as he has 3,028 passing yards, 22 TD's and eight interceptions.

The pick: The 49ers are fighting to stay alive in the playoff hunt after a slow start, due mostly to injury and COVID. San Fran snapped its three-game losing streak last time out as its finally adjusting on the offensive side with Nick Mullens under center. So far Mullens has 1,642 passing yards, six touchdowns and seven interceptions. San Fran averages 23.7 PPG and it allows 23.1, but note that it's seen the total fly "over" the number in four of its last six vs. Buffalo. The Bills have seen the total fly over in four of their last five on the road and all signs point to these strong trends continuing here. This number is a little low.

This is a 10* TOTAL OF THE WEEK on the OVER Buffalo/San Fran.