The set-up: These teams are moving in opposite directions. San Francisco has dropped two straight and with a loss today, it'll be officially eliminated from contention. It's been an uphill battle for the 49ers this year, who come to town without their starting QB and several other key players on both sides of the ball. With the rest of the division healthy and playing well, I think the 49ers throw in the white flag here early.

The pick: Dallas snapped a two-game slide with a 30-7 win over the Bengalas last weekend. The Cowboys are in such a weak division, that if they win today and the other three teams lose, then they're going to be back in the drivers seat (and that's a very real possibility, as Philly is in Arizona, the Giants are at home to a smoking hot Browns team, and Washington is at home to the Seahawks without Alex Smith under center. The Cowboys have plenty of talent on the offensive side of the ball and backup Andy Dalton finally seems to be getting up to speed. The Dallas defense looked better last weekend too and now it faces another offense with its back up QB under center. This one has blowout written all over it in my opinion, but may as well grab the points.

This is an 8* DESTRUCTION on the Dallas Cowboys.