The set-up: Whether Patrick Mahomes plays or not, I think the Chiefs are deep and talented enough to pull off a victory here at home over the Bills. Buffalo is now definitely in unchartered territory. With Josh Allen under center, this Bills team has a shot at competing with any team in the league. Buffalo's weakness this year is definitely on the defensive side of the ball though and I think that'll be its downfall finally here in this difficult road venue.

The pick: The Chiefs have had lapses in concentration this year (lost at home to the Raiders), but overall the reason they eclipsed their team season win total for an eighth straight year was because of an improved defense. KC is loaded with offensive and defensive talent and I like Andy Reid to have a masterful plan cooked up here to deal with the potential of Mahomes being sidelined. The game of Football is about more than just one player obviously and in this case, I think that the defending champs still have more than enough pieces in place to pull off another victory and advance to the Super Bowl. I'm laying the points!

The is a 10* GAME OF THE WEEK on the KC Chiefs.