The set-up: Zack Greinke will help his team break its current six game slide. Greinke is looking to bounce back after a poor outing vs. the Tigers, allowing six runs over 4.2 innings. The Mariners are in a rebuilding year, but they're somehow atop the AL West with an 8-5 record. Seattle starter Chris Flexen was crushed in his opener as well, getting shelled for five runs off eight hits over five innings in a setback to the Twins.

The pick: I give the advantage for sure in this spot to the veteran Greinke, who has the track record and pedigree to make some minor adjustments and take full advantage of this advantageous matchup. I think Houston is the better team in every regard and despite some injuries, I look for it to finally get untracked here with its ace on the mound.

This is a 10* DESTRUCTION on the Astros.