We have not yet seen a USC game go under 58 points this season, and even without Caleb Williams, expect the Trojans to do their part in contributing to the scoring.
Since last season, the over is 20-6 in USC games, the highest over rate in the country, including a 46-45 bowl loss to Tulane last season.
Louisville has put up 31+ in four of their last five, and should be able to cook the USC defense.
3% on over.