Indianapolis at San Francisco 8:20 ET
49ers (-) over Colts- Indianapolis has come to life winning two of their last three with the loss in OT against the Ravens in Baltimore as Carson Wentz has shown flashes of his former self. San Francisco has now dropped three straight after opening the season with a pair of victories and are 1-4 ATS and is off a bye week after a 17-10 loss at Arizona. Jimmy Garoppolo will be back under center returning from a calf injury that sidelined him and gave rookie Trey Lance a start and now he is on the injured list. The Colts who is 7-2 ATS in their last nine road games are also 4-0 SU in the last four meetings. The Niners have struggled as favorites going 5-22-1 ATS in that role as hosts and 10-27 ATS as favorites in their last 37 overall. Don't let those numbers hold you back as SF is off a bye week and get the win here. Rake SAN FRANCISCO!