I think the loss of Jadveon Clowney on the defensive side of the ball though is obviously a huge hole for Houston to fill besides their offensive line issues.

Saints QB Drew Brees, who has won 24 games combined over the last two seasons. Brees has extremely skilled offensive weapons around him this year in Alvin Kamara and Michael Thomas and I expect them to expose this weakened Houston defense. The Saints have always enjoyed a strong home-field advantage and the Texans are a poor 3 ATS wins in their last 11 on the road. Houston is also 3-10 against the spread in their last 13 contests on Monday Night. New Orleans has used that high octane offense to power the over to a 4-1 record in their last five on MNF.
I'm taking the Saints here tonight.